MyBioSource.com's Mouse Anti-PITX2 Antibody is a Mouse monoclonal antibody. The Mouse Anti-PITX2 Antibody was generated using PITX2, Pitx2c, and RGS as the antigen. It reacts with Human. This antibody has been shown to work in applications such as: ELISA, Immunofluorescence, and Western Blot.
Description
Pilx2 is a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. This protein acts as a transcription factor and regulates procollagen lysyl hydroxylase gene expression. It plays a role in the terminal differentiation of somatotroph and lactotroph cell phenotypes, is involved in the development of the eye, tooth and abdominal organs, and acts as a transcriptional regulator involved in basal and hormone-regulated activity of prolactin. Mutations in this protein are associated with Axenfeld-Rieger syndrome, iridogoniodysgenesis syndrome, and sporadic cases of Peters anomaly. A similar protein in other vertebrates is involved in the determination of left-right asymmetry during development